Xiaflex

Xiaflex (Collagenase clostridium histolyticum) is a new non-surgical treatment for adults with Dupuytren's Contracture with a palpable cord. It has been offered by the expert Hand Specialists at the Northeast Center for Dupuytren's Contracture and Central Jersey Hand Surgery since it's release in the Spring of 2010. All doctors at our center are trained and experienced in the proper use and administration of Xiaflex.

Dupuytren's contracture causes a progressive, abnormal thickening of the tissue in the palm of the hand. Over time, a rope-like cord pulls the finger permanently toward your palm. This bend, called a contracture, reduces the range of motion and prevents full straightening of the finger(s).

Xiaflex is a prescription medicine, which is injected directly into a Dupuytren's cord. No incision or open surgery is required. The procedure is done in our office and does not usually require therapy visits after treatment. Xiaflex helps "dissolve" the cord that is causing the finger to be bent.

Dr. Pess recently gave three presentations on Xiaflex including these photos and videos. The first presentation was at the Annual Meeting of the American Academy for Orthopedic Surgeons in San Diego, CA in February, 2011. The second was at the Spring Meeting of the British Society for the Surgery of the Hand Meeting in the U.K. in April, 2011. In September, 2001, he spoke at the American Society for Surgery of the Hand Annual Meeting in Las Vegas.

The expert Hand Specialists at the Northeast Center for Dupuytren's Contracture and Central Jersey Hand Surgery also perform Needle Aponeurotomy (NA), another minimally invasive treatment for Dupuytren's Contracture. You can find more information about Needle Aponeurotomy (NA) on the Dupuytren's Contracture web page.

Here are a few cases with photos and videos demonstrating the procedure and showing the excellent results achieved.

Xiaflex Procedure

Patient 1


Injection procedure performed in the office for a 63 y/o patient with a mild 30° MP joint contracture right ring finger

Manipulation procedure performed the next day

Patient 2


Injection procedure performed in the office for a 84 y/o patient with a severe 79° PIP joint contracture left ring finger

Manipulation procedure performed the next day

Patient 3


Xiaflex injection procedure performed in the office for a 55 y/o patient with a severe 76° PIP joint contracture left little finger. He has already had multiple NA and Open Fasciectomy procedures with residual scarring.


Manipulation procedure performed the next day

Patient 4





51 y/o patient with severe contracture of MP joint 59° and PIP joint 78° right ring finger




Beautiful result achieved post-manipulation
Side Effects/Important Notes

Common side effects of Xiaflex include swelling of the injection site or the hand, bleeding or bruising at the injection site, pain or tenderness of the injection site or the hand, swelling of the lymph nodes (glands) in the elbow or underarm, itching, breaks in the skin, redness or warmth of the skin, and pain in the underarm. Xiaflex can cause severe side effects which include tendon rupture, pulley damage, ligament damage, nerve injury and allergic reaction.

If you would like to start the insurance approval and scheduling process for Xiaflex, please call Lisa directly at 732-542-4477 x206 or email her
at: lisacjhs@gmail.com

If you are interested in finding out more information about Needle Aponeurotomy (NA), please go to our Dupuytren's Contracture page.

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Eatontown, NJ 07724-2265
(732) 542-4477

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535 Iron Bridge Road
Freehold, NJ 07728-5301
(732) 462-7700

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780 Route 37 West, Suite 140
Toms River, NJ 08755-6431
(732) 286-9000

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